2 Introduction

In this vignette, we will explore the OmopSketch functions designed to provide an overview of the observation_period table. Specifically, there are six key functions that facilitate this:

2.1 Create a mock cdm

Let’s see an example of its functionalities. To start with, we will load essential packages and create a mock cdm using the mockOmopSketch() database.

library(dplyr)
library(OmopSketch)

# Connect to mock database
cdm <- mockOmopSketch()

3 Summarise observation periods

Let’s now use the summariseObservationPeriod() function from the OmopSketch package to help us have an overview of one of the observation_period table, including some statistics such as the Number of subjects and Duration in days for each observation period (e.g., 1st, 2nd)

summarisedResult <- summariseObservationPeriod(cdm$observation_period)

summarisedResult
#> # A tibble: 3,102 × 13
#>    result_id cdm_name       group_name      group_level strata_name strata_level
#>        <int> <chr>          <chr>           <chr>       <chr>       <chr>       
#>  1         1 mockOmopSketch observation_pe… all         overall     overall     
#>  2         1 mockOmopSketch observation_pe… all         overall     overall     
#>  3         1 mockOmopSketch observation_pe… all         overall     overall     
#>  4         1 mockOmopSketch observation_pe… all         overall     overall     
#>  5         1 mockOmopSketch observation_pe… all         overall     overall     
#>  6         1 mockOmopSketch observation_pe… all         overall     overall     
#>  7         1 mockOmopSketch observation_pe… all         overall     overall     
#>  8         1 mockOmopSketch observation_pe… all         overall     overall     
#>  9         1 mockOmopSketch observation_pe… all         overall     overall     
#> 10         1 mockOmopSketch observation_pe… all         overall     overall     
#> # ℹ 3,092 more rows
#> # ℹ 7 more variables: variable_name <chr>, variable_level <chr>,
#> #   estimate_name <chr>, estimate_type <chr>, estimate_value <chr>,
#> #   additional_name <chr>, additional_level <chr>

Notice that the output is in the summarised result format.

We can use the arguments to specify which statistics we want to perform. For example, use the argument estimates to indicate which estimates you are interested regarding the Duration in days of the observation period.

summarisedResult <- summariseObservationPeriod(cdm$observation_period,
  estimates = c("mean", "sd", "q05", "q95")
)

summarisedResult |>
  filter(variable_name == "Duration in days") |>
  select(group_level, variable_name, estimate_name, estimate_value)
#> # A tibble: 8 × 4
#>   group_level variable_name    estimate_name estimate_value  
#>   <chr>       <chr>            <chr>         <chr>           
#> 1 all         Duration in days mean          4735.76         
#> 2 all         Duration in days sd            4363.77402714669
#> 3 all         Duration in days q05           145             
#> 4 all         Duration in days q95           13017           
#> 5 1st         Duration in days mean          4735.76         
#> 6 1st         Duration in days sd            4363.77402714669
#> 7 1st         Duration in days q05           145             
#> 8 1st         Duration in days q95           13017

Additionally, you can stratify the results by sex and age groups, and specify a date range of interest:

summarisedResult <- summariseObservationPeriod(cdm$observation_period,
  estimates = c("mean", "sd", "q05", "q95"),
  sex = TRUE,
  ageGroup = list("<35" = c(0, 34), ">=35" = c(35, Inf)),
  dateRange = as.Date(c("1970-01-01", "2010-01-01"))
)

summarisedResult |>
  select(group_level, variable_name, strata_level, estimate_name, estimate_value) |>
  glimpse()
#> Rows: 135
#> Columns: 5
#> $ group_level    <chr> "all", "all", "all", "all", "all", "all", "all", "all",…
#> $ variable_name  <chr> "Number records", "Number subjects", "Records per perso…
#> $ strata_level   <chr> "overall", "overall", "overall", "overall", "overall", …
#> $ estimate_name  <chr> "count", "count", "mean", "sd", "q05", "q95", "mean", "…
#> $ estimate_value <chr> "99", "74", "1", "0", "1", "1", "3664.89898989899", "28…

Notice that, by default, the “overall” group will be also included, as well as crossed strata (that means, sex == “Female” and ageGroup == “>35”).

3.1 Tidy the summarised object

tableObservationPeriod() will help you to create a table (see supported types with: visOmopResults::tableType()). By default it creates a gt table.

summarisedResult <- summariseObservationPeriod(cdm$observation_period,
  estimates = c("mean", "sd", "q05", "q95"),
  sex = TRUE
)

summarisedResult |>
  tableObservationPeriod()
#> ℹ <median> [<q25> - <q75>] has not been formatted.
Observation period ordinal Variable name Estimate name
CDM name
mockOmopSketch
overall
all Number records N 100
Number subjects N 100
Records per person mean (sd) 1.00 (0.00)
Duration in days mean (sd) 4,735.76 (4,363.77)
1st Number subjects N 100
Duration in days mean (sd) 4,735.76 (4,363.77)
Female
all Number records N 59
Number subjects N 59
Records per person mean (sd) 1.00 (0.00)
Duration in days mean (sd) 4,630.83 (4,556.62)
1st Number subjects N 59
Duration in days mean (sd) 4,630.83 (4,556.62)
Male
all Number records N 41
Number subjects N 41
Records per person mean (sd) 1.00 (0.00)
Duration in days mean (sd) 4,886.76 (4,121.24)
1st Number subjects N 41
Duration in days mean (sd) 4,886.76 (4,121.24)

3.2 Visualise the results

Finally, we can visualise the result using plotObservationPeriod().

summarisedResult <- summariseObservationPeriod(cdm$observation_period)

plotObservationPeriod(summarisedResult,
  variableName = "Number subjects",
  plotType = "barplot"
)

Note that either Number subjects or Duration in days can be plotted. For Number of subjects, the plot type can be barplot, whereas for Duration in days, the plot type can be barplot, boxplot, or densityplot.”

Additionally, if results were stratified by sex or age group, we can further use facet or colour arguments to highlight the different results in the plot. To help us identify by which variables we can colour or facet by, we can use visOmopResult package.

summarisedResult <- summariseObservationPeriod(cdm$observation_period,
  sex = TRUE
)
plotObservationPeriod(summarisedResult,
  variableName = "Duration in days",
  plotType = "boxplot",
  facet = "sex"
)


summarisedResult <- summariseObservationPeriod(cdm$observation_period,
  sex = TRUE,
  ageGroup = list("<35" = c(0, 34), ">=35" = c(35, Inf))
)
plotObservationPeriod(summarisedResult,
  colour = "sex",
  facet = "age_group"
)

4 Summarise in observation

OmopSketch can also help you to summarise the number of records in observation during specific intervals of time.

summarisedResult <- summariseInObservation(cdm$observation_period,
  interval = "years"
)

summarisedResult |>
  select(variable_name, estimate_name, estimate_value, additional_name, additional_level)
#> # A tibble: 136 × 5
#>    variable_name   estimate_name estimate_value additional_name additional_level
#>    <chr>           <chr>         <chr>          <chr>           <chr>           
#>  1 Number records… count         1              time_interval   1952-01-01 to 1…
#>  2 Number records… count         2              time_interval   1953-01-01 to 1…
#>  3 Number records… count         2              time_interval   1954-01-01 to 1…
#>  4 Number records… count         2              time_interval   1955-01-01 to 1…
#>  5 Number records… count         2              time_interval   1956-01-01 to 1…
#>  6 Number records… count         2              time_interval   1957-01-01 to 1…
#>  7 Number records… count         2              time_interval   1958-01-01 to 1…
#>  8 Number records… count         2              time_interval   1959-01-01 to 1…
#>  9 Number records… count         2              time_interval   1960-01-01 to 1…
#> 10 Number records… count         2              time_interval   1961-01-01 to 1…
#> # ℹ 126 more rows

Note that you can adjust the time interval period using the interval argument, which can be set to either “years”, “quarters”, “months” or “overall” (default value).

summarisedResult <- summariseInObservation(cdm$observation_period,
  interval = "months"
)

summarisedResult |>
  select(variable_name, estimate_name, estimate_value, additional_name, additional_level)
#> # A tibble: 1,630 × 5
#>    variable_name   estimate_name estimate_value additional_name additional_level
#>    <chr>           <chr>         <chr>          <chr>           <chr>           
#>  1 Number records… count         1              time_interval   1952-02-01 to 1…
#>  2 Number records… count         1              time_interval   1952-03-01 to 1…
#>  3 Number records… count         1              time_interval   1952-04-01 to 1…
#>  4 Number records… count         1              time_interval   1952-05-01 to 1…
#>  5 Number records… count         1              time_interval   1952-06-01 to 1…
#>  6 Number records… count         1              time_interval   1952-07-01 to 1…
#>  7 Number records… count         1              time_interval   1952-08-01 to 1…
#>  8 Number records… count         1              time_interval   1952-09-01 to 1…
#>  9 Number records… count         1              time_interval   1952-10-01 to 1…
#> 10 Number records… count         1              time_interval   1952-11-01 to 1…
#> # ℹ 1,620 more rows

Along with the number of records in observation, you can also calculate the number of person-days by setting the output argument to c(“record”, “person-days”).


summarisedResult <- summariseInObservation(cdm$observation_period, 
                                           output = c("record", "person-days"))                                        


summarisedResult |>
  select(variable_name, estimate_name, estimate_value, additional_name, additional_level)
#> # A tibble: 4 × 5
#>   variable_name    estimate_name estimate_value additional_name additional_level
#>   <chr>            <chr>         <chr>          <chr>           <chr>           
#> 1 Number person-d… count         473576         overall         overall         
#> 2 Number records … count         100            overall         overall         
#> 3 Number person-d… percentage    100.00         overall         overall         
#> 4 Number records … percentage    100.00         overall         overall

We can further stratify our counts by sex (setting argument sex = TRUE) or by age (providing an age group). Notice that in both cases, the function will automatically create a group called overall with all the sex groups and all the age groups. We can also define a date range of interest to filter the observation_period table accordingly.


summarisedResult <- summariseInObservation(cdm$observation_period, 
                                           output = c("record", "person-days"),
                                           interval = "quarters",
                                           sex = TRUE, 
                                           ageGroup = list("<35" = c(0, 34), ">=35" = c(35, Inf)), 
                                           dateRange = as.Date(c("1970-01-01", "2010-01-01")))                                        


summarisedResult |>
  select(strata_level, variable_name, estimate_name, estimate_value, additional_name, additional_level)
#> # A tibble: 1,676 × 6
#>    strata_level   variable_name     estimate_name estimate_value additional_name
#>    <chr>          <chr>             <chr>         <chr>          <chr>          
#>  1 Male &&& <35   Number person-da… count         90             time_interval  
#>  2 Male           Number person-da… count         90             time_interval  
#>  3 Female         Number person-da… count         90             time_interval  
#>  4 Female &&& <35 Number person-da… count         90             time_interval  
#>  5 Female         Number records i… count         1              time_interval  
#>  6 Male           Number records i… count         1              time_interval  
#>  7 Female &&& <35 Number records i… count         1              time_interval  
#>  8 Male &&& <35   Number records i… count         1              time_interval  
#>  9 Male &&& <35   Number person-da… count         92             time_interval  
#> 10 Male           Number person-da… count         92             time_interval  
#> # ℹ 1,666 more rows
#> # ℹ 1 more variable: additional_level <chr>

You can include additional output metrics by them to the output argument:

If output = "person", the trend in the number of individuals in observation is returned.

summarisedResult <- summariseInObservation(cdm$observation_period, 
                                           output = c("person"),
                                           interval = "years",
                                           sex = TRUE, 
                                           ageGroup = list("<35" = c(0, 34), ">=35" = c(35, Inf)), 
                                           )                                        


summarisedResult |>
  select(strata_level, variable_name, estimate_name, estimate_value, additional_name, additional_level)
#> # A tibble: 986 × 6
#>    strata_level   variable_name     estimate_name estimate_value additional_name
#>    <chr>          <chr>             <chr>         <chr>          <chr>          
#>  1 Female &&& <35 Number subjects … count         1              time_interval  
#>  2 Female         Number subjects … count         1              time_interval  
#>  3 Female &&& <35 Number subjects … count         2              time_interval  
#>  4 Female         Number subjects … count         2              time_interval  
#>  5 Female &&& <35 Number subjects … count         2              time_interval  
#>  6 Female         Number subjects … count         2              time_interval  
#>  7 Female         Number subjects … count         2              time_interval  
#>  8 Female &&& <35 Number subjects … count         2              time_interval  
#>  9 Female         Number subjects … count         2              time_interval  
#> 10 Female &&& <35 Number subjects … count         2              time_interval  
#> # ℹ 976 more rows
#> # ℹ 1 more variable: additional_level <chr>

If output = "sex", the trend in the number of females in observation is returned. If sex = TRUE is specified, this stratification is ignored.

summarisedResult <- summariseInObservation(cdm$observation_period, 
                                           output = c("sex"),
                                           interval = "years",
                                           sex = TRUE, 
                                           ageGroup = list("<35" = c(0, 34), ">=35" = c(35, Inf)), 
                                           )                                        


summarisedResult |>
  select(strata_level, variable_name, estimate_name, estimate_value, additional_name, additional_level)
#> # A tibble: 342 × 6
#>    strata_level variable_name       estimate_name estimate_value additional_name
#>    <chr>        <chr>               <chr>         <chr>          <chr>          
#>  1 <35          Number females in … count         1              time_interval  
#>  2 overall      Number females in … count         1              time_interval  
#>  3 <35          Number females in … count         2              time_interval  
#>  4 overall      Number females in … count         2              time_interval  
#>  5 <35          Number females in … count         2              time_interval  
#>  6 overall      Number females in … count         2              time_interval  
#>  7 overall      Number females in … count         2              time_interval  
#>  8 <35          Number females in … count         2              time_interval  
#>  9 <35          Number females in … count         2              time_interval  
#> 10 overall      Number females in … count         2              time_interval  
#> # ℹ 332 more rows
#> # ℹ 1 more variable: additional_level <chr>

If output = "age, the trend in the median age of the population in observation is calculated. If ageGroup and interval are both specified, the age is computed at the beginning of the interval or of the observation period, whichever is more recent.

summarisedResult <- summariseInObservation(cdm$observation_period, 
                                           output = c("age"),
                                           interval = "years",
                                           ageGroup = list("<35" = c(0, 34), ">=35" = c(35, Inf)), 
                                           )                                        
#> Warning: Missing values are always removed in SQL aggregation functions.
#> Use `na.rm = TRUE` to silence this warning
#> This warning is displayed once every 8 hours.


summarisedResult |>
  select(strata_level, variable_name, estimate_name, estimate_value, additional_name, additional_level)
#> # A tibble: 171 × 6
#>    strata_level variable_name       estimate_name estimate_value additional_name
#>    <chr>        <chr>               <chr>         <chr>          <chr>          
#>  1 overall      Median age in obse… median        2              time_interval  
#>  2 <35          Median age in obse… median        2              time_interval  
#>  3 <35          Median age in obse… median        1              time_interval  
#>  4 overall      Median age in obse… median        1              time_interval  
#>  5 <35          Median age in obse… median        2              time_interval  
#>  6 overall      Median age in obse… median        2              time_interval  
#>  7 overall      Median age in obse… median        3              time_interval  
#>  8 <35          Median age in obse… median        3              time_interval  
#>  9 <35          Median age in obse… median        4              time_interval  
#> 10 overall      Median age in obse… median        4              time_interval  
#> # ℹ 161 more rows
#> # ℹ 1 more variable: additional_level <chr>

4.1 Tidy the summarised object

tableInObservartion() will help you to create a table of type gt, reactable or datatable. By default it creates a gt table.

summarisedResult <- summariseInObservation(cdm$observation_period, 
                                           output = c("person", "person-days", "sex"),
                                           sex = TRUE)

summarisedResult |>
  tableInObservation(type = "gt")
Variable name Estimate name Sex
Database name
mockOmopSketch
Number person-days N (%) Female 273219 (57.69%)
Number subjects in observation N (%) Female 59 (59.00%)
Number person-days N (%) Male 200357 (42.31%)
Number subjects in observation N (%) Male 41 (41.00%)
Number females in observation N (%) overall 59 (59.00%)
Number person-days N (%) overall 473576 (100.00%)
Number subjects in observation N (%) overall 100 (100.00%)

4.2 Visualise the results

Finally, we can visualise the trend using plotInObservation().

summarisedResult <- summariseInObservation(cdm$observation_period,
  interval = "years"
)
plotInObservation(summarisedResult)
#> `result_id` is not present in result.
#> `result_id` is not present in result.

Notice that one output at a time can be plotted. If more outputs have been included in the summarised result, you will have to filter to only include one variable at time.

Additionally, if results were stratified by sex or age group, we can further use facet or colour arguments to highlight the different results in the plot. To help us identify by which variables we can colour or facet by, we can use visOmopResult package.


summarisedResult <- summariseInObservation(cdm$observation_period, 
                       interval = "years",
                       output = c("record", "age"),
                       sex = TRUE,
                       ageGroup = list("<35" = c(0, 34), ">=35" = c(35, Inf))) 
plotInObservation(summarisedResult |> 
  filter(variable_name == "Median age in observation"),
  colour = "sex", 
  facet = "age_group")
#> `result_id` is not present in result.
#> `result_id` is not present in result.

Finally, disconnect from the cdm

PatientProfiles::mockDisconnect(cdm = cdm)